W 5 3 Mutations Emerge at Early Phase of Myelodysplastic Syndrome and Are Associated With Complex Chromosomal Abnormalities
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چکیده
We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reactionmediated single-strand conformation polymorphism (PCRSSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mutations were detected at the presentation of MDS whether these patients showed leukemic transformation or not. TP53 mutations were frequently found in patients with loss of the short arm
منابع مشابه
Mutations Emerge at Early Phase of Myelodysplastic Syndrome and Are Associated With Complex Chromosomal Abnormalities
We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reactionmediated single-strand conformation polymorphism (PCRSSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mutations were detected at the presentation of MDS whether these patients showed l...
متن کاملTP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities.
We examined TP53 mutation in 57 patients with myelodysplastic syndrome (MDS) at either the MDS phase or at the terminal leukemic phase using polymerase chain reaction-mediated single-strand conformation polymorphism (PCR-SSCP) analysis. TP53 mutations within exons 5 through 8 were found in seven patients. All these mutations were detected at the presentation of MDS whether these patients showed...
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تاریخ انتشار 2000